Moreover, we compared the differences in the intensity of immunostaining of ERK1/2, p38, β‐catenin, and E‐cadherin in the control group—between BPH stroma and BPH epithelium and—showed that lower immunoreactivity of MAPK and Wnt/β‐catenin pathway proteins in BPH stroma compared to epithelium may indicate differential activity of these pathways in individual tissue regions. The gene discussed is MAPK1; the disease is benign prostatic hyperplasia.