PTGS2 (degree = 14) amplifies inflammatory cascades by converting FASN-derived arachidonic acid into protumorigenic prostaglandin E2, establishing a self-perpetuating lipid-inflammation feedforward loop that drives IL-6/STAT3-mediated malignant transformation in non-alcoholic steatohepatitis [44, 45]. Here, STAT3 is linked to metabolic dysfunction-associated steatohepatitis.