The search strategy was designed by three authors (M.M, I.Z., and S.M.)and approved by all the other scientists, combining the following medical subject headings (MeSH) terms: “interleukin-8” or “IL-8” or “CXCL-8” or “CXCL8”, and “carcinoma” or “RCC” or “cancer” or “ccRCC” or “chRCC” or “pRCC”. The gene discussed is CXCL8; the disease is nonpapillary renal cell carcinoma.