CXCL8 and colorectal carcinoma: In our previous meta-analysis conducted in CRC, the impact of IL-8 on OS appeared to be slightly more evident in subgroups of patients treated with anti-angiogenic agents as compared with chemotherapy46; nevertheless, the benefit of adding anti-angiogenic agents to standard treatment or placebo in individual studies did not differ between high and low circulating IL-8 levels.47