We also noticed that an average of 44% rWT- and 51% rH234A-infected cells show PABPC1 cytoplasmic puncta, although the percentages do not statistically differ between the two infections (Fig. S5), consistent with the notion that PABPC1 cytoplasmic puncta formation can be RNase L-independent (16, 18). Here, RNASEL is linked to infection.