To determine whether SARS-CoV-2 EndoU antagonizes OAS/RNase L activation in human lung epithelial cells, we first performed RNA TapeStation analysis of total RNA extracted from A549-A cells following virus infection (MOI 5) to detect rRNA degradation, a hallmark of OAS/RNase L-mediated RNA decay (Fig. 6A). This evidence concerns the gene RNASEL and viral infectious disease.