In the present study, we investigated the effects of IL‐5 vaccination on allergen‐specific IgE levels and Th1/Th2 cytokine modulation in two species with skin allergy: an induced skin allergy model in mice using ovalbumin mimicking allergic dermatitis; and a naturally occurring equine skin allergy, IBH, an allergy towards insect bites. Here, IL5 is linked to allergic disease.