Indeed, OVA‐challenged mice (VLP + OVA), served as positive control, showed a significant increase in anti‐OVA IgE (Figure S3A) and anti‐OVA IgG (Figure S3B), when compared to negative control group (VLP + PBS), indicating a successful OVA sensitization of OVA‐induced dermatitis mice. This evidence concerns the gene IGHE and skin disorder.