We assessed the NP and NPR regulatory networks across various tissues, focusing on internal organs including Head, Body, Testis, Antenna, Body wall, Fat body, Gut, Haltere, Heart, Leg, Male reproductive glands, Malpighian tubule, Oenocyte, Ovary, proboscis, and maxillary palps, Trachea, and Wing, where transcriptional regulation is crucial for metabolism and infection responses [84, 85, 86, 87, 88, 89]. The gene discussed is NPTXR; the disease is infection.