According to the study by Bosch et al., reduced LH and FSH action may stem not only from congenital causes or receptor polymorphisms, but also to acquired causes (eating disorders, excessive exercise, age-related GnRH pulse deterioration), organic causes (tumors, radiotherapy, trauma or glandular surgery) or use of GnRH analogues (14). The gene discussed is PLOD1; the disease is eating disorder.