It has been proposed that chemokines such as CXC-chemokine-ligand-12 (CXCL12), also known as stromal-cell derived factor 1 (SDF-1), be used to reverse the migration of GBM cells invading the brain parenchyma to trap them in an alginate hydrogel (Molina-Peña et al., 2021; Solano et al., 2021; El Kheir et al., 2022; Safi et al., 2022). The gene discussed is CXCL12; the disease is glioblastoma.