Other complications noted through chart review included new or worsening hypertension (n=2, 14%), gastroesophageal reflux disease (n=2, 14%), recurrent hospitalizations for acute decompensated heart failure (n=1, 7%), duodenal ulcer (n=1, 7%), and worsening diabetes (n=1, 7%, with HbA1c improving from 11% to 5.5% after discontinuation of Artri King; insulin, metformin, and empagliflozin were all titrated off due to hypoglycemia). The gene discussed is INS; the disease is hypertensive disorder.