The search strategy included a combination of Medical Subject Headings (MeSH) and free-text terms related to GLP-1 receptor agonists (e.g., “semaglutide,” “liraglutide,” and “GLP-1 agonist”), obesity management, long-term efficacy, weight maintenance, and safety outcomes. This evidence concerns the gene GLP1R and obesity due to melanocortin 4 receptor deficiency.