AQP4 expression is immediately and significantly increased in the lesion core, and then AQP4 expression in the lesion core was gradually decomposed within several hours after stroke, and only expressed in the peri-lesion (Wang and Parpura, 2016; Ribeiro Mde et al., 2006; Huang et al., 2013). The gene discussed is AQP4; the disease is Stroke.