Additionally, cancer cells that are resistant to therapy and exhibit certain cellular characteristics are susceptible to ferroptosis; for instance, cancer cells displaying a mesenchymal phenotype often accumulate PUFAs due to elevated expression of zinc finger E-box binding homeobox 1 (ZEB1), elongation of very long-chain fatty acid protein 5 (ELOVL5), or fatty acid desaturase 1 (FADS1), which make them vulnerable to ferroptosis. This evidence concerns the gene ZEB1 and cancer.