Sheets et al.21 reported a patient with e1a3 BCR-ABL fusion transcript in acute myeloid leukemia, he received dasatinib therapy and achieved MRD+ CR after 3 months diagnosis, but relapsed with a T315I mutation and again achieved CR on ponatinib, while subsequently relapsed and died of progressive AML. Here, ABL1 is linked to acute myeloid leukemia.