Through pooled analysis of potential associated factors, we identified demographic characteristic (age), IIM subtype (CADM), clinical manifestations (mechanic’s hands, fever, dysphagia, and pulmonary infection), antibody activities (anti-MDA5 antibody and anti-Ro-52 antibody), and laboratory data (ferritin >336 ng/mL, LDH > 280 U/L, ESR > 21 mm/h, CRP > 0.05 mg/L, AST >36 U/L, and ALT >27.75 U/L) as associated risk factors for RP-ILD development, while longer disease duration and dysphagia were potential protective factors. The gene discussed is TRIM21; the disease is interstitial lung disease.