In conclusion, our pooled analyses showed that advanced age, CADM, mechanic’s hands, fever, dysphagia, pulmonary infection, anti-MDA5 antibody, anti-Ro-52 antibody, ferritin (>336 ng/mL), LDH (>280 U/L), ESR (>21 mm/h), CRP (>0.05 mg/L), AST (>36 U/L), and ALT (>27.75 U/L) were risk factors for RP-ILD development in IIM patients. The gene discussed is TRIM21; the disease is interstitial lung disease.