HLA-DRB1*03:01 is associated with acute, self-limiting sarcoidosis (e.g., Löfgren syndrome), characterized by transient Th1/Th17 activation and spontaneous resolution, whereas HLA-DRB1*15:01 is linked to chronic, progressive disease, marked by persistent Th1/Th17 responses and immune tolerance failure (35, 141). The gene discussed is HLA-DRB1; the disease is sarcoidosis.