Clinico-pathological correlations further reveal that sustained UA elevation may perpetuate chronic inflammation through positive feedback loops involving CRP (r = 0.42, p < 0.001), TNF-α (r = 0.38, p = 0.002), and IL-6 (r = 0.35, p = 0.005), suggesting that hyperuricemia serves as a biomarker and a pathogenic indicator in RA-related systemic inflammation (16). This evidence concerns the gene TNF and hyperuricemia.