The analysis showed that female sex, age, smoking, rheumatoid factor (RF), erythrocyte sedimentation rate (ESR), disease activity score 28 (DAS28), C-reactive protein (CRP), high UA, aspartate aminotransferase (AST), white blood cell count (WBC), neutrophil ratio (NEUT %), fibrinogen (FIB), albumin (ALB), globulin (GLB), cystatin C (Cys-C), glucocorticoids (GCs) use, immunosuppressive drug (ISD) use, diuretics use, and chronic lung disease (CLD) were all statistically significant risk factors for the incidence of ILD in RA patients (Table 2). This evidence concerns the gene CST3 and rheumatoid arthritis.