After adjusting for the covariates, including age, ethnicity, PIR, education, physical activity, BMI, CRP, SIRI, hypertension, dyslipidemia, CVD, and an anti-platelet agent, we found that higher levels of PLP were associated with the lower risk of LF (OR = 0.44, 95% CI: 0.35–0.56), and higher 4-PA/PLP ratio (≥0.939) was associated with the higher risk of LF (OR = 2.69, 95% CI: 1.87–3.86). This evidence concerns the gene CRP and Hypertension.