Second, considering that the epidemiological attributes of LF are influenced by numerous factors, such as demographic characteristics and health status, we accounted for the confounding variables, including age, race, PIR, educational attainment, physical activity, BMI, energy consumption, CRP, SIRI, hypertension, dyslipidemia, CVD, and anti-platelet medication, to enhance the precision of the analytical outcomes. This evidence concerns the gene CRP and hypertensive disorder.