AKT1 and cardiac hypertrophy: Additional gain- and loss-of-function experiments in neonatal rat cardiomyocyte further corroborated the role of ADAMT2 as a negative regulator of cardiac hypertrophy, seemingly through down-regulating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway, a known key contributor to cardiac hypertrophy.45