Given the essential role of TGFβ signaling in the progression of cardiovascular disease,125 Huang and coworkers recently analyzed the expression pattern of TGFβ-related genes during the progress of heart failure and cardiac hypertrophy, using public single-cell RNA sequencing and transcriptome datasets of heart failure and hypertrophic cardiomyopathy.49 The gene discussed is TGFB1; the disease is cardiac hypertrophy.