The significance of coiled-coil-containing proteins extends to the realm of oncology, with mounting evidence indicating that their dysregulated expression is implicated in the neoplastic behavior of various cancers.6, 7, 8 Furthermore, coiled-coil domain-containing 109B (CCDC109B) has emerged as an oncogene and a prognostic indicator in gliomas.9 The gene discussed is MCUB; the disease is glioma.