In patients with DKD, the expression levels of junctional adhesion molecule-like protein (JAML), sterol regulatory element-binding protein-1 (SREBP-1), and carbohydrate response element-binding protein (ChREBP) were found to be positively correlated with serum creatinine levels and renal lipid accumulation, but negatively correlated with the eGFR. The gene discussed is SREBF1; the disease is diabetic kidney disease.