Its multi-component synergistic action provides a potential strategy for intervening in kidney damage related to dysphilia.Using methods such as PCR,Western blot analysis, and immunofluorescence, we validated that WYJDTLF can significantly inhibit the JAML/SIRT1 signalling pathway, thereby alleviating inflammatory responses, reducing the production of JAML and mSREBP1 that lead to lipid deposition, and promoting the production of SIRT1, which counteracts lipid deposition. The gene discussed is JAML; the disease is Nephropathy.