In patients with DKD, the expression levels of junctional adhesion molecule-like protein (JAML), sterol regulatory element-binding protein-1 (SREBP-1), and carbohydrate response element-binding protein (ChREBP) were found to be positively correlated with serum creatinine levels and renal lipid accumulation, but negatively correlated with the eGFR. This evidence concerns the gene JAML and diabetic kidney disease.