TG and autoimmune thyroid disease: Certain peptides play significant roles in regulating autoimmune responses; for example, the human thyroglobulin (hTg) p2340 peptide can induce autoimmune thyroiditis in HLADR3 transgenic mice [45], indicating that some thyroid- related peptides can induce T cell-mediated immune responses via HLA-DR binding, leading to thyroid tissue damage [45], [46].