It was found by binary multivariate Logistic regression analysis, the relevant predictors of postoperative LNM in EGC patients were tumour size (OR: 2.582, 95% CI: 1.205–5.534), depth of invasion (OR: 2.953, 95% CI: 1.327–6.573), vascular invasion (OR: 2.724, 95% CI: 1.241–5.976), neuroaggression (OR: 2.681, 95% CI: 1.139–6.311), differentiation type (OR: 2.426, 95% CI: 1.140–5.119) and P53 (OR: 3.133, 95% CI: 1.183~8.301), P<0.05, as shown in Table 3. Here, TP53 is linked to neoplasm.