Binary multivariate logistic regression analysis identified the following as significant predictors of postoperative LNM in EGC patients: tumour size (OR: 2.582, 95% CI: 1.205-5.534), depth of invasion (OR: 2.953, 95% CI: 1.327-6.573), vascular invasion (OR: 2.724, 95% CI: 1.241-5.976), neuroaggression (OR: 2.681, 95% CI: 1.139-6.311), differentiation type (OR: 2.426, 95% CI: 1.140-5.119), and P53 (OR: 3.133, 95% CI: 1.183-8.301), P<0.05. Here, TP53 is linked to neoplasm.