BUN, blood urea nitrogen;<br>CKD, chronic kidney disease;<br>CRS, cardiorenal syndrome;<br>CVOT, cardiovascular outcome trials;<br>eGFR, estimated glomerular filtration rate;<br>ESRD, end-stage renal disease;<br>HbA1c, glycated haemoglobin A1c;<br>LVEDD, left ventricular end-diastolic diameter;<br>LVEF, left ventricular ejection fraction,<br>MACE, major adverse cardiovascular events,<br>SGLT2, sodium-glucose cotransporter 2,<br>T2DM, type 2 diabetes mellitus. This evidence concerns the gene SLC5A2 and type 2 diabetes mellitus.