The results of our study indicated that after intervention, Hb, ALB and TP levels in the SG presented higher when compared with the CG, IgA, IgM and IgG levels in the SG presented higher when compared with the CG, and RCSQ scores in the SG presented higher when comparing with the CG, implying that nutritional support combined with stratified nursing under delirium risk assessment strategy could promote the nutritional status, immune function and sleep quality of elderly hip fracture patients after surgery. This evidence concerns the gene GSTM1 and hip fracture.