Paricalcitol is a selective VD receptor agonist which improves vitamin deficiency and interacts with EPO to promote the synthesis and secretion of EPO, promote erythropoiesis in the bone marrow and increase erythropoietin sensitivity [28]; cinacalcet is a calcamodulin that can significantly improve renal anaemia when treated with cinacalcet. This evidence concerns the gene EPO and vitamin deficiency.