Paricalcitol is a selective VD receptor agonist which improves vitamin deficiency and interacts with EPO to promote the synthesis and secretion of EPO, promote erythropoiesis in the bone marrow and increase erythropoietin sensitivity [28]; cinacalcet is a calcamodulin that can significantly improve renal anaemia when treated with cinacalcet. The gene discussed is EPO; the disease is vitamin deficiency disorder.