Notably, the gene expression of IFNAR1, IFNGR1 but not IFNLR1 (Figure S5B) and protein expression of IFNAR2 (Figure S5C) were detectable in NK cell clusters from HD and patients suffering from chronic HBV or HCV infection and STAT1 and/or STAT4 were phosphorylated upon type-I and -II IFN stimulation (Figures 3B, S5D, and S5E). Here, IFNLR1 is linked to Huntington disease.