Further studies found that post-stroke exercise reduced the activation of M1 microglia and serum levels of TNF-α and IL-1β, reversed the increase in the number of tunel-positive cells and the Bax/Bcl-2 ratio, and attenuated the inflammatory response and apoptosis in the stroke rats by inhibiting the MAPK pathway, resulting in the improvement of function (98). This evidence concerns the gene IL1B and stroke disorder.