Treadmill training induces the expression of calcium/calmodulin-dependent protein kinase II α isoform (Camk2a) through the upregulation of cytoplasmic FMR1-interacting protein 1 (CYFIP1), which enhances synaptic plasticity and dendritic remodeling of the ischemic hemi-dark band, thereby improving functional recovery in stroke mice (81). Here, CYFIP1 is linked to stroke disorder.