Constraint-induced movement therapy (CIMT) may promote remodeling of motor cortex neurons, neurofilaments, dendritic/axonal regions and myelin sheaths by partially inhibiting the Nogo-A/NgR/RhoA/ROCK pathway, and increase the expression of growth-associated protein 43 (GAP-43), synaptophysin, vGlut1, and PSD-95 in the disinnervated cervical spinal cord, which may promote the improvement of motor function in hemiplegic cerebral palsy mice with improved motor function (75, 76). Here, GAP43 is linked to cerebral palsy.