Aerobic exercise intervention significantly down-regulated the expression levels of pro-inflammatory cytokine IL-1β and chemokine MCP-1 in brain tissues of post-stroke rats and improved motor function, prevented neuronal cell death and inhibited the activation of microglia and astrocytes, suggesting that exercise has a certain role in regulating inflammatory responses after cerebral ischaemia (99). The gene discussed is IL1B; the disease is stroke disorder.