IL1B and Stroke: Further studies found that post-stroke exercise reduced the activation of M1 microglia and serum levels of TNF-α and IL-1β, reversed the increase in the number of tunel-positive cells and the Bax/Bcl-2 ratio, and attenuated the inflammatory response and apoptosis in the stroke rats by inhibiting the MAPK pathway, resulting in the improvement of function (98).