BNIP3 and kidney cancer: Based on the previous findings of this study, the expression level of BNIP3 is low in kidney cancer cell lines (8), and based on this, this project intends to construct BNIP3-overexpressing kidney cancer cells to explore whether HIF can interact with BNIP3 to mediate the occurrence of autophagy and affect the growth and programmed cell death of malignant cells.