RAC1 and non-small cell lung carcinoma: Additionally, non - small cell lung cancer (NSCLC) - derived lncRNA - SOX2OT regulates osteoblast differentiation and stimulates bone metastasis by targeting the miRNA - 194 - 5p/RAC1 axis and the TGF - β/PTHRP/RANKL signaling pathway in osteoblasts (63).