A significant decrease in PKC activity in the cytosol and membrane fractions of prefrontal and temporal cortex was present in participants with bipolar disorder, but not schizophrenia, affecting all classic PKC isoforms (PRKCA, PRKB-I, PRKB-II, PRKCG) (Pandey et al., 2020). This evidence concerns the gene PRRT2 and bipolar disorder.