PRRT2 and bipolar disorder: Unopposed antidepressant therapy is known to lead to manic switch in a modest proportion of bipolar disorder patients (Gorwood et al., 2016), but this does not occur in the context of a mood-stabilizer or neuroleptic use (Bhowmik et al., 2014), highlighting the complex effects of antidepressants in specific vulnerable populations, beyond its effect on PKC attenuation.