A recent study by Zheng et al. (Zheng et al., 2025) demonstrated that methyltransferase-like protein 4 (METTL4)-mediated N6-methyldeoxyadenosine (6 mA) modification of mitochondrial DNA (mtDNA) induces mitochondrial damage and inflammatory responses in macrophages, thereby promoting the development of atherosclerosis. This evidence concerns the gene METTL4 and atherosclerosis.