ELN and endothelial dysfunction: In one study, 12-month-old mice exposed to prenatal hypoxia (12% oxygen, GD 15−20) had mild endothelial dysfunction, but when it was combined with a high-salt postnatal diet (5% NaCl), offspring had mesenteric artery stiffening and changes in the extracellular matrix composition of the aorta, including a marked loss of elastin fibre integrity [30].