PRKAA1 and pulmonary arterial hypertension: The putatively adaptive PRKAA1 promoter variant may also be important to neonatal lung development after birth and enhanced AMPK-α1 expression to adulthood, and could also explain the postnatal persistence of pulmonary hypertension in Andeans [71], given that AMPK-α1 facilitates hypoxic pulmonary vasoconstriction [72].