P4HB and cancer: Collectively, the findings of this study, along with our recent observations[15], jointly demonstrate a pivotal role of PDI in SAS-induced ferroptosis through the activation of the PDI→NOS→NO→ROS/lipid-ROS pathway and offer new strategies for sensitizing cancer cells to SAS-induced ferroptosis, such as through the use of NO-releasing agents or TrxR1 inhibitors.