MGMT and glioblastoma: Firstly, dose‐response analyses on four patient‐derived GBM cell lines (GBM03, GBM06, GBM14, and GBM15) with distinct molecular features, including methylated and unmethylated MGMT promoters (Table 1), revealed nanomolar‐range sensitivity to THZ1 (Figure 1A), accompanied by DNA damage response activation and apoptosis (Figure 1B).