Proposed mechanisms for this AE include reduced goblet cell density due to IL‐13 inhibition, altered mucin production, increased Demodex mite density, and immune dysregulation in conjunctival‐associated lymphoid tissue, frequent eye rubbing in AD subjects which acts as a mechanical and inflammatory amplifier in an already vulnerable ocular environment (patients with blepharitis and/or conjunctivitis before starting treatment) [25, 26, 27, 28]. Here, IL13 is linked to Alzheimer disease.