This pathway included several chromatin-related regulators uniquely found in the WFSD-defined severe group, including CBX4, KMT2E, ZMYND11, and PRPF8. CBX4 is a component of the Polycomb Repressive Complex 1, which is associated with NDD and has previously been highlighted as an ASD risk gene in network-based analyses [56, 57]. This evidence concerns the gene KMT2E and Neurodevelopmental delay.