GBA1 and Parkinson disease: To this end, we engineered PEG-PBAE NPs carrying plasmid DNA (pDNA) encoding human GBA1 gene (PEG-PBAE/pGBA1) and investigated the therapeutic potential as a DMT for PD in an α-syn preformed fibril (PFF)-induced mouse model of PD following intracranial convection-enhanced delivery (CED).