ESR1 and neoplasm: Additional factors such as age, tumor size (before and after NACT), multifocality, and biologic characteristics such as ER/HER2– status and lymphovascular invasion also have been reported.19–29 Our multivariable analyses confirmed that the size of the largest metastatic deposit in SLN, the ratio of positive SLNs, extracapsular extension, cT-stage, and multifocality were associated with additional axillary disease.