SARM1 and neoplasm: Notably, in Sarm1−/− mice, the tumours also appeared overall more diffuse compared with the WT controls, as judged by smaller proportions of tumours forming a defined bulk, lower tumour density and increased tumour area on the basis of both fluorescence imaging and H&E assessment (Fig. 5a–d, Extended Data Fig. 8a and Supplementary Data 2).