This may result from intratumoral heterogeneity – demonstrated, for example, by the variable expression of WT1 in HGSC_3, and also CK7 in SBT/LGSC_1 (Figs. 3D and 4C) – coupled with selection pressure within the culture, induced by media composition, thus favouring specific tumour subpopulations. Here, WT1 is linked to neoplasm.