To address this important biomedical knowledge gap, we determined cell-type-level DNA methylation, chromatin conformation and gene expression signatures in SAT, assessed the involvement of methylation pathway genes in SAT cell-type-level dynamic methylation patterns, identified cell-type-level hypomethylated region-associated transcription factor (TF) binding motifs and investigated the contribution of variants in SAT cell-type-level epigenomic sites to polygenic risk of abdominal obesity and a related inflammatory marker, blood C-reactive protein (CRP). The gene discussed is CRP; the disease is Abdominal obesity.