Increased expression of both PHLDA3 in not sun-exposed skin (p = 1.74 × 10-14, OR = 2.39 [1.91 – 2.99]) and NEDD4 in fibroblasts (p = 5.90 × 10-11, OR = 1.91 [1.57 – 2.31]) were associated with increased risk of keloids. The gene discussed is NEDD4; the disease is keloid.