PSMB8 and lipodystrophy: Furthermore, several autoinflammatory syndromes associated with acquired fat loss, such as joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced lipodystrophy (JMP) syndrome [112], Japanese autoinflammatory syndrome with lipodystrophy [113] and chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome [114] have been associated with PVs of the proteasome subunit beta-type 8 (PSMB8) gene.