For example, the activating receptor KIR2DS2 binds HLA-C*01:02 with six salt bridges [32] and the two activating receptors associated with type 1 diabetes progression, KIR2DS3 and KIR2DS5, are predicted to form four or five additional salt bridges with HLA-B*51:01 and HLA-A*25:01, respectively, substantially enhancing electrostatic binding energy. The gene discussed is HLA-B; the disease is type 1 diabetes mellitus.