These gene expression profiles suggest that APOE-high myeloid cells in metastatic LNs exhibit characteristics of tumor associated macrophages (TAMs) with pro-tumor properties25–27 and this finding is consistent with recently reported data showing the immunosuppressive role of APOE-expressing macrophages existing in primary tumor mass of gastric cancers, melanoma, and other types of cancer27–29. This evidence concerns the gene APOE and neoplasm.