Upon comparison of gene expression patterns between APOE-high myeloid cells in the control and metastatic LN groups, we found that the biological pathways related to angiogenesis, epithelial-mesenchymal transition (EMT), inflammatory response, and hypoxia were enriched in the APOE-high myeloid cells of the metastatic LN group (Fig. 3B). Here, APOE is linked to lobular neoplasia.