Compared to the control LN group, the metastatic LN group uniquely displays enrichment of the SPP1 and FN1 signaling pathways with APOE-high myeloid cells serving as senders and other immune cells, such as CD8 T cells, CD4 T cells, Treg, and NK cells, serving as receivers (Fig. 5D). The gene discussed is SPP1; the disease is lobular neoplasia.