Although we could not further dissect CD8 T cells into sub-clusters because of the limited cell numbers in the EBUS samples, the co-existence of cytotoxic effector and exhausted transcriptomic programs in CD8 T cells suggests that intrathoracic LNs in metastatic disease harbor a heterogeneous population of CD8 T cell subsets with specific phenotypes that favor cancer progression. The gene discussed is CD8A; the disease is cancer.