According to the 2021 World Health Organization (WHO) Classification of Gliomas, adult-type diffuse astrocytic tumors are grouped based on isocitrate dehydrogenase (IDH) mutation status, with only IDHwildtype tumors with either characteristic morphology or molecular features of glioblastoma being classified as “glioblastoma, IDHwildtype"3. The gene discussed is IDH3A; the disease is central nervous system cancer.