In contrast, Cx31-depleted HCC1143 GJB3Low cells formed tangential contacts with adjacent adipocytes (Fig. 3d and Supplementary Fig. 3a, middle), which we note closely mimic the tangential cancer cell-adipocyte conformation observed in T47D (RP) co-cultures (Fig. 3d and Supplementary Fig. 3a, bottom). Here, GJB3 is linked to cancer.