CASP8 and neoplasm: Radiotherapy-induced CRT upregulation can improve antitumor effects of anti-PD-L1 treatment in caspase-8 knockout tumors because the knockout of caspase-8 suppresses the translocation of CRT to the surface of tumor cells, which impairs phagocytosis function and antigen presentation of DCs and the infiltration of tumor-specific CD8+ T cells [123].