However, Shen, W. et al. indicated that radiotherapy combined with CD24/Siglec-10 blockade has a synergistic anti-tumor efficiency compared with their treatment as single agents by increasing the percentage of IFNγ-expressing CD8+ T cells, ratio of M1/M2 macrophages, and proportion of monocytic MDSCs in colon cancer [106] (Table 2). Here, CD8A is linked to neoplasm.