HCMV replication in infected cells in culture is known to require COX-2 expression for the production of PGE2,68–69,75,103–104 and PGE2 directly upregulates the HCMV major immediate early promoter in macrophages.104 Additionally, HCMV infection of various cell lines upregulates 5-LO and COX-2 expression68–71 and can increase the production of LTB4.71 Interestingly, we found that leukotrienes and PGE2 were present at steady state in the NM, lungs, and SG, with quantities in the lung being markedly higher than the NM or SG (Fig. 2). Here, PTGS2 is linked to cytomegalovirus infection.