PTGS2 and cancer: Moreover, the activation of COX-2 and 5-LO by HCMV has been proposed to act as a driver of cancer by mediating inflammation and angiogenesis.76–77,72–74 In addition, it will be important to determine how the balance between pro-inflammatory and pro-resolving mediators impacts viral loads, persistence, and pathogenesis by selectively targeting pro-resolving signaling pathways.